I've been using lobelia off and on for 5 yrs with no ill effect.
Combined with sage it's a brilliant expectorant, clears out lung pollution

Hits the dopamine receptors.

Potentiates the effects of other drugs, leading to lower doses needed for those effects.
Conversely other drugs such as other piperidines like chilis potentiate lobeline.

This website explains a lot;
https://restorativemedicine.org/jour...atory-illness/