I have a 4 page paper my friends father wrote in 1958. They were studying the use of LSD on mental patients.

He took the acid at 9:00 am and wrote his personal experiences throughout the day. Not scientific notes but his feelings. He said he wanted to experience it before they tried it in therapy. One key thing I remember him saying was he couldn't get the little record player loud enough and at full volume it sounded incredible.

Recently I have heard of therapy with mushrooms as well. Interesting stuff.