Nutrients That Reduce the Negative Effects of PM2.5 Pollution
Intake of essential micronutrients such as B vitamins and omega-3 polyunsaturated fatty acids have been found to reduce the harmful effects of air pollution
According to a report by the World Health Organization, ambient fine particulate matter (i.e. PM2.5) pollution caused some 3 million premature deaths worldwide, making it one of the most deadliest environmental toxins.
Even at levels below regulatory levels, associations of PM2.5 exposure with increased cardiovascular and mortality risk have been found in sensitive individuals including the elderly, and those suffering from asthma, diabetes and cardiovascular disease.
At the individual level, besides installing appropriate air cleaning devices in our working and living spaces and wearing protective mask when necessary, we can also protect ourselves through a healthy diet and smart use of supplements.
Research has found that some nutrients can indeed help to boost our resistance to inhaled environmental pollutants and reduce or neutralize their negative health effects. Below we highlight 3 prominent ones you can use to fight against air pollutants.
Fish Oil
Some evidence suggests that exposure to ambient PM2.5 can lead to a decrease in heart rate variability among susceptible populations (1, 2, 3). Heart rate variability (HRV) is a measurement of the variation in time of successive heart beats. Generally, less variability is an indicator of body stress and diseases. Several studies have also associated reduced HRV with higher risk of cardiovascular events and all-cause death (4, 5, 6).
There are studies suggesting that omega-3 polyunsaturated fatty acids from fish oil may help to blunt the negative effects of PM2.5 on HRV in elderly adults.
In a randomized controlled trial in Mexico City, 50 elderly residents of a nursing home were supplemented with 2 g per day of either fish oil or soy oil for five months (7). In the soy oil group, the high frequency component of heart rate variability (HF-HRV) was decreased by 54% per one standard deviation increase in indoor PM2.5, while only a 7% decrease in HF-HRV was observed after supplementing with fish oil.
Another study compared the effects of supplementing with fish oil against olive oil (3 g/day for four weeks) on healthy middle aged participants who were exposed to either filtered air or concentrated ambient fine particles for 2 hours (8). Cardiac responses were assessed by comparing HRV and electrocardiographic repolarization changes measured before, immediately after, and 20-hour after exposure. Changes in plasma lipids were also evaluated. The study found that omega-3 fatty acids protected against the adverse cardiac and lipid effects associated with air pollution exposure, while olive oil offered little to no protection.
The effects of omega-3 fatty acid on the oxidative response induced by exposure to PM2.5 was also investigated in another elderly population from Mexico City (9).
Inhaled air pollutants, such as PM2.5, can react with antioxidants found in the respiratory tract lining fluids (RTLFs) such as reduced glutathione (GSH) and superoxide dismutase (SOD) (10). These antioxidants are one of the body’s initial defense against inhaled environmental toxins and therefore, could be an important determinant of individual susceptibility to air pollutants.
The study found that omega-3 intake from fish oil (2 g per day) for four months has been found to increase SOD activity by 49% and GSH level by 62%, while decreasing oxidation of lipids by 72%. Thus, it appears that omega-3 fatty acids are able to modulate PM2.5 induced oxidative stress by increasing the activity of antioxidants in the RTLFs.
Vitamin C & E
Vitamin C and E are key lipid-soluble and water-soluble antioxidants in humans that may be helpful in reducing air pollution-induced oxidative stress.
The effect of vitamin C and E was evaluated in a study on individuals exposed directly or indirectly to coal burning emissions from an electric-power plant (11).
Oxidative stress biomarkers were measured before and after supplementation with vitamin C (500 mg) and vitamin E (800 mg) for six months and compared to a non-exposed control group.
In individuals exposed to airborne pollutants, markers of lipid and protein damage increased and the levels of non-enzymatic antioxidants (vitamin E, reduced glutathione and protein thiols) decreased.
The activities of several enzymes involved in the antioxidant defense system (catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase) were impaired, while the activity of superoxide dismutase increased, suggesting increased utilization of antioxidants and activation of the oxidative stress defense system in the presence of inhaled pollutants.
In these subjects, supplementing with vitamin C and E helped to reduce markers of lipid and protein damage and improved both enzymatic and non-enzymatic antioxidant defenses.
B Vitamins
B vitamins refer to a group of water-soluble vitamins that play important roles in cell metabolism. Each B vitamin is either a cofactor for key metabolic processes or is a precursor needed to make one.
In a human trial, 10 healthy adults were given fake pills (placebo) for two weeks and were then exposed to sham, particle-free medical air for 2 hours (12). This was followed by another four weeks of fake pills before the participants were exposed to concentrated ambient PM2.5 (250 μg/m3) for 2 hours. Finally, participants were given B vitamin tablets for another four weeks and then exposed to polluted air for 2 hours again. Resting heart rate (HR), heart rate variability (HRV), total white blood cell (WBC) counts, and lymphocyte (a type of white blood cell) count were measured before, immediately after and 24-hour after each exposure.
Results show that compared to sham, exposure to ambient PM2.5 for two hours increased HR, WBC count, lymphocyte count, and reduced HRV in healthy adults.
However, an intake of B vitamins for four weeks (once a day; each tablet contains 2.5 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12) reduced PM2.5 effect on heart rate by 150%, HRV by 90%, WBC count by 139%, and lymphocyte count by 106%.
A separate study evaluated the effects of air pollution, genetic variations in metabolic genes and dietary intake of methyl nutrients (folate, vitamin B6, vitamin B12 and methionine from food sources) on HRV (13).
It found that people who carry certain genes which put them at a higher risk of cardiovascular disease had a significantly more pronounced decrease in HRV than those without when exposed to ambient PM2.5.
In addition, higher dietary intake of vitamin B6 (≥ 3.65 mg/day), vitamin B12 (≥ 11.1 µg/day), folate (≥ 495.8 µg/day) and methionine (≥ 1.88 mg/day) is found to negate the negative effects of PM2.5 on HRV.
The protective effects of B vitamins may be due to their anti-inflammatory, antioxidant and immuno-epigenetic properties. In the presence of air pollution, adequate vitamin B intake ensures proper epigenetic status of white blood cells (leukocytes), enabling the cells to carry out their immuno-regulation job properly, as well as prevents excessive oxidative damage to the cardiovascular system (14).