Simple.
Big Pharma, a term of reference, implies mega-industrial scale pharmacy, manufacturing and distributing all forms of pharmaceuticals ona global scale.
Working for Olin I was involved in accounting for both incoming and outgoing goods, as well as later on shuffled up into credit control only.
Initially, in training, I worked both bought and credit ledgers and cross refered to sales and costs dept.
I knew how much material, of what form, the cost etc came in, how much went out as manufactured product and so on, right down to how much profit we made per pill of Raudixin a heart tab popular at the time.
The factory floor was awash with chemicals of all forms, and the Raudixin (speed) tabs powder was regularlly snaffled by workers,.....lots.
Around once a month, office staff were given the dubious privilege of being guinnea pigs for our latest product, paid anything up to 2 weeks wages a go, three or four days with a patch on your arm or a shot, then checked out.
That was R and D of ER Squibb Olin Mathieson UK. back then, manufacturing chemists.
We sold bulk all sortsa medicines/products to most major global warehouses and distributors, we were all together essentially Big Pharma, along with all other phrmacological mamufacturers and chemical suppliers in the world at that time.
Big pharma exists, it's a sel-protecting trading froup wiyh fingers in so many pies you'd never believe.
Up, behind it all is ICI and Olin.