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  1. #101
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    Quote Originally Posted by Henrie View Post
    90mg per kilo over 24 hours is 1800 mg over 24 hours. Did you child consume the 500mg (or more) over a gentle 24 hours or in the space of a single minute?

    Jesus this guy is a tool.
    She took it in one dose obviously.
    The more I read the more concerned I am to tell the truth.

  2. #102
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    ^ Good. Then I'm pleased that I may have helped with that and my first day in my new home hiding from the sun hasn't been entirely wasted
    It's cooling down a bit so I'm going out to explore.

  3. #103
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    Has someone sent a link to this thread to mumsnet?

    Cujo you plonker

  4. #104
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    I'm repeating this in case you missed it due to posting at the same time.

    Sitting around waiting for any symptoms to occur, which you have indicated you are doing, is crazy.

    Quote Originally Posted by Henrie View Post
    An injection of common sense from the Australian government to one of its clueless citizens living in China.

    https://www.betterhealth.vic.gov.au/.../drug-overdose

    Paracetamol is a common pain reliever and fever reducer that is usually bought over the counter without a prescription. It is one of the most common medicines taken by young children in an accidental overdose.

    There is only a small difference between the maximum daily dose of paracetamol and an overdose, which can cause liver damage. Large amounts of paracetamol are very dangerous, but the effects often don’t show until about two to three days after taking the tablets. However, treatment must be started early to be effective, before the effects begin.

    Always seek treatment for paracetamol overdose immediately, even if the person seems quite well.
    Choosing to live in a country where you are scared of the doctors is a lame excuse not to.

  5. #105
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    I never figured Cujo to be a hysterical neurotic. Funny how things go.

    One paracetamol tablet isn't going to matter diddlysquat. Just make sure she doesn't whack down a quart of Scotch - the combination is bad for the liver.

  6. #106
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    Quote Originally Posted by Seekingasylum View Post
    One paracetamol tablet isn't going to matter diddlysquat.
    I agree and it's too late to do anything anyway. But I'd be very concerned if it was three, the equivalent of an adult male taking 12.

  7. #107
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    You are making assumptions here. The dosage is approximate and in truth is nowhere near as much as that indicated, particularly here in Thailand and taking into account degradation. There is also the question of metabolism of the drug as it progresses through the system and generally only a proportion, usually between 50 - 75%, of the active ingredient actually gets absorbed through the stomach etc into the bloodstream.

    Given this and the reasonable certainty that she only took one tablet, which she doubtless chewed thereby reducing the drug efficacy further, I think Cujo's disquiet would be better focused on something more worthy, such as chance decapitation by a frisbee thrown by a one-eyed Lascar recently discharged from a ship in Shanghai.

  8. #108
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    Seeking, please get your facts strait before posting about something you know absolutely nothing about. Absorption of regular release acetaminophen is actually 85-98%, not the 50-75% you state. It also might help if you quote sources.

    Absorption

    Regular-Release

    Oral acetaminophen is rapidly and almost completely absorbed from the gastrointestinal tract primarily in the small intestine. This absorption process occurs by passive transport. The relative bioavailability ranges from 85% to 98%.15
    15. McGilveray IJ, Mattok GL, Fooks JR, Jordan N, Cook D. Acetaminophen II: a comparison of the physiological availabilities of different commercial dosage forms. Can J Pharmaceut Sci. 1971;6:38-42.
    Tylenol (Acetaminophen) Drug Information: Clinical Pharmacology - Prescribing Information at RxList

    Your comment about chewing a tablet is also false.
    Last edited by rickschoppers; 30-12-2015 at 03:51 PM.

  9. #109
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    Quote Originally Posted by Seekingasylum View Post
    You are making assumptions here. The dosage is approximate and in truth is nowhere near as much as that indicated, particularly here in Thailand and taking into account degradation. There is also the question of metabolism of the drug as it progresses through the system and generally only a proportion, usually between 50 - 75%, of the active ingredient actually gets absorbed through the stomach etc into the bloodstream.
    You are making a common double deduction mistake. The toxicity levels are based on the amount ingested not the final amount absorbed, and assume average degradation. To base it on the final amount absorbed is dangerous.



    Quote Originally Posted by Seekingasylum
    Given this and the reasonable certainty that she only took one tablet
    Cujo is in two minds about whether he used two or four of the five missing tablets himself. In such circumstances medical professionals take a worst case scenario approach and would assume that the girl had ingested three tablets.

  10. #110
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    Quote Originally Posted by Henrie
    and would assume that the girl had ingested three tablets.
    Which is still 5 less than 8.

  11. #111
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    Chipping in with an 'eight' comment long after this figure has been moved on makes you look a tit.

    I won't bother hitting the view post button again for any of your shit.

  12. #112
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    Quote Originally Posted by Henrie
    Chipping in with an 'eight' comment long after this figure has been moved on
    Nope, don't think it has.


    PS: I know who the tit is.

  13. #113
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    Quote Originally Posted by Henrie View Post

    Minimum toxic doses of acetaminophen for a single ingestion, posing significant risk of severe hepatotoxicity, are as follows:

    Adults: 7.5-10 g
    Children: 150 mg/kg; 200 mg/kg in healthy children aged 1-6 years
    Read carefully and firstly realise that this is a level causing significant risk and severe damage, and secondly it is over a 24 hour period of ingestion.
    Uh, no its not. As underlined, its for a single ingestion (as underlined).

    Which works out at 8 tablets. As has been said all along.

  14. #114
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    8 tablets blah blah. So foolish.

    8 tablets are highly toxic in a 4.5 year old and will likely prove fatal. 3 tablets are toxic and will likely cause some permanent liver damage, with death possible in some. Fine if you guys are only interested in the former.

  15. #115
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    Still trolling.

    I thought you were leaving ?

  16. #116
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    Cujo, did you tell the wife?

  17. #117
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    Quote Originally Posted by Dillinger View Post
    Cujo, did you tell the wife?
    Yes, I wanted to make sure she was OK when the missus picked her up after school.

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