I'm not sure F16's will be enough to gain air superiority, although it could, for limited area and time, to inflict tactical advantages.
Much will depend on the weapons and ew protection supplied. I hope they will, for instance, be able to detect an incoming r37 and suppress that threat. Also the Russian SAM sites are a real threat and need to be neutralised.
Unfortunately an effective campaign will see substantial losses. That has to happen if Ukraine seek an effective counter using combined air and heavy armour strikes. At least in the early stages.