Originally Posted by
Hans Mann
Charlie Sheen Stopped Taking His HIV Meds
In an appearance on the Dr. Oz Show on Tuesday, Charlie Sheen confessed that he had stopped taking medicine to manage his HIV and sought alternate treatment in Mexico via a doctor who promised him a cure.
Sheen told Dr. Oz that the side effects of his medicine were too much to bear. While HIV medications are more effective than ever, some people do continue to experience side effects, often stomach-related, from their regimens.
So what happens when patients go off their meds? Dr. Anthony Urbina, associate professor of medicine at Mt. Sinai Hospital, broke it down to Mic this way.
HIV, which hijacks a person's immune system, rebounds when a person goes stops taking treatment. At that point, the virus has the opportunity to infect new cells as well as penetrate deeper into the HIV reservoir, a store of HIV-infected cells in the body that's unaffected by medication. Treatment holidays, scheduled breaks when people stop taking their HIV meds, also became popular in the late 1990s and early 2000s, though, Urbina said, most infectious disease doctors would urge patients to steer clear of them now.
"The way you develop resistance is if you take your pills 40% to 70% of the time," Urbina told Mic. "If you stop them altogether, you won't have any drug on board to select for resistance."
Urbina said that, of those HIV-positive patients in the Mt. Sinai system on medication, close to 90% take their medication, which is higher than the 37% average nationwide. When on a successful treatment plan, a person who takes medications is undetectable, which means they're healthy and do not transmit the virus. However, not everyone can stay on top of their regimen.