Study finds antidepressants no better than sugar pills
Feb 27, 2008 04:30 AM
Study: Four of the most commonly prescribed antidepressants, including Prozac, work no better than placebo sugar pills to help mild to moderate depression, says a study published in
PloS (Public Library of Science)
Medicine. Irving Kirsch of the department of psychology at Hull University in England and colleagues in the U.S. and Canada compared trial results for patients taking a sugar pill with those given the antidepressants fluoxetine (Prozac), paroxetine (Seroxat), venlafaxine (Effexor) and nefazodone (Serzone). They found that patients felt better but those on placebos improved as much as those on the drugs. The only exception: the most severely depressed did better on the drugs.
Method: Using freedom of information rules, researchers obtained a full set of trial data from the U.S. Food and Drug Administration, including results the drug companies had chosen not to publish.
Background: Prozac has been used by 40 million patients since 1988.
Claim: "There seems little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed to provide a benefit," Kirsch says. Alternatives include talk therapy.
Caveat: Patients are strongly advised not to stop taking medication without consulting their doctor. "This analysis has only examined a small subset of the total data available while regulatory bodies around the world have conducted extensive reviews and evaluations of all the data available," says GlaxoSmithKline, which makes Seroxat. Eli Lilly, maker of Prozac, also defended research showing the antidepressant is effective.
Second Opinion examines health studies.
Source: The Guardian, BBC News.
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