Patrick Mahomes, Travis Kelce and the Chiefs are chasing a historic three-peat; Jalen Hurts, Saquon Barkley and AJ Brown are looking to gain revenge for the Eagles.
Kansas City won a 38-35 thriller in 2023 in Arizona and something like that again will go down very nicely.
The Eagles generally have the better side, a star-studded roster, but the Chiefs have that winning mentality and have been grinding out close victories all season.
So who will lift the Vince Lombardi Trophy in the Superdome on Sunday?
Why would Super Bowl three-peat be so special?
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Media caption,Mahomes best plays as Chiefs seek historic three-peat
Just getting this far is already historic. No previous back-to-back champion has made it to the Super Bowl the following season.
Many neutrals hoped the Buffalo Bills, led by this season's Most Valuable Player Josh Allen, would make it to Super Bowl 59.
But the Chiefs beat them 32-29 in the AFC Conference Championship and as they clinched victory, the team's play-by-play announcer Mitch Holthus said the Chiefs had "gone past Pluto".
"To get to this point, to go further than any team has ever been, it transcends the NFL and becomes part of world sport history," he told BBC Sport.
"But to win this game, I think it would be an achievement that would never be done again."
This is Kansas City's fifth Super Bowl in six years and they are going for a fourth win.
Many neutrals are bored of seeing them win; some have even claimed they receive preferential treatment from officials.
When hosting the NFL's annual awards on Thursday, rapper Snoop Dogg even joked that Sunday's game will be an "incredible match-up between the Eagles... and the refs".
But Holthus dismissed that as a "false narrative" and this week NFL commissioner Roger Goodell said it was "ridiculous", while Mahomes is happy to keep being "a villain".