Thread: Miserable bastards might be demented instead

People with early-onset dementia are often mistaken for having depression and now Australian research has discovered the cause: a profound loss of ability to experience pleasure - for example a delicious meal or beautiful sunset - related to degeneration of 'hedonic hotspots' in the brain where pleasure mechanisms are concentrated.

The University of Sydney-led research revealed marked degeneration, or atrophy, in frontal and striatal areas of the brain related to diminished reward-seeking, in patients with frontotemporal dementia (FTD).

The researchers believe it is the first study to demonstrate profound anhedonia - the clinical definition for a loss of ability to experience pleasure - in people with FTD.

Anhedonia is also common in people with depression, bipolar disorder and obsessive-compulsive disorder and can be particularly disabling for the individual.

In the study, patients with FTD - which generally affects people aged 40-65 - displayed a dramatic decline from pre-disease onset, in contrast to patients with Alzheimer's disease, who were not found to show clinically significant anhedonia.

The results point to the importance of considering anhedonia as a primary presenting feature of FTD, where researchers found neural drivers in areas that are distinct from apathy or depression.

The findings were published today in the leading neuroscience journal, Brain.

Profound loss of pleasure related to early-onset dementia | EurekAlert! Science News

Jaysus, more than a few TD posters are presenting with FTD...

Originally Posted by TheRealKW

FTD

fcuking the dog ? is it wrong to take pleasure in that ?

The problem in divining just who may be suffering from this deficiency is that the older we more intelligent and sophisticated get, the less likely we are to be titillated by what the lumpen and hoi polloi might find stimulating.

A glorious Titian sunset is indeed a sight but I have to say after a lifetime of them one is unmoved now. And as much as I enjoy a fine paella valenciana washed down by a bottle of Faustino followed by a tarte tatin dolloped with clotted cream, it is scarcely a memory of any note.

My pleasure receptors are now much more refined and seem to focus on deriving a satisfaction, lifting my spirits, from observing the misfortune of others who irritate me.

Given that we are now in the Age of The Stupid when the hubristic are getting fucked royally there seems no end to my fun.

Schadenfreude, you can't beat it.

At least you have the excitment of finding out if you can use the pool daily, that's got to keep you on your toes.

Originally Posted by strigils

At least you have the excitment of finding out if you can use the pool daily, that's got to keep you on your toes.

But how can that compare with the heady days of trying to smuggle sausages into entertainment venues?

Its funny how the little pikey screams if you call him out on things he's sensitive about, loves to dish but can't take it which is a bit hypoctical given his

Originally Posted by Seekingasylum

focus on deriving a satisfaction, lifting my spirits, from observing the misfortune of others who irritate me.

I mean, locking your retirement cash into the Thai condo market, unable to leave a country in which you are surrounded by people you loath and all the while repeatedly calling others stupid. It really is

Originally Posted by Seekingasylum

Schadenfreude, you can't beat it.

Originally Posted by strigils

Its funny how the little pikey screams if you call him out on things he's sensitive about, loves to dish but can't take it which is a bit hypoctical given his



I mean, locking your retirement cash into the Thai condo market, unable to leave a country in which you are surrounded by people you loath and all the while repeatedly calling others stupid. It really is

Originally Posted by nidhogg

But how can that compare with the heady days of trying to smuggle sausages into entertainment venues?

Cant.

He's moving back to BKK so we could have a sequel.

Fucking hell. Tax and seeking ass? That title was like flypaper.....

Quite telling the posts that have been deleted from this thread

^

TEFLERS. Gotta love em.......

Originally Posted by nidhogg

^

TEFLERS. Gotta love em.......

Do not give TEFLERS a bad name in this case. Much too broad of a stereotype.

Originally Posted by taxexile

s.a.


that just about sums it up perfectly.

there is fun to be had poking a stick at some of the angrier and more sensitive characters here, baiting them with observations and insults and knowing that in their umbrage they cannot resist replying in an idiotic, infantile, repetitive and self righteous manner, usually but not always including false accusations of miserableness, ethnicity, failure, homosexuality, being old, hypersexuality ( in the case of m.m.) and dementia.

surely the main purpose of a gutter forum like this is for the wiser, erudite and more perceptive amongst us to insult and banter with those here who for reasons i cannot begin to fathom choose to reveal intimate details of their lives. and their predictable responses merely confirm their utter and sheer idiocy.

long live the human zoo that is teak door, and in particular the pack of neanderthal apes (and baboons) who make a visit here so much fun.

So tax do you think it's possible we have misjudged you, and that in fact you are not a miserable bastard after all?

^ He just plays one on TD.

Originally Posted by aging one

Do not give TEFLERS a bad name in this case. Much too broad of a stereotype.

My bad. Never put you in the tefler class......

Originally Posted by misskit

^ He just plays one on TD.

When in fact he's demented.

This thread will never end up in the DH, its lacking at least 3 key players

The point is of course, those who are mere Brexit buffoons and fodder for the blue-collar machine, so exemplified by Numfuktwat and the Cockwomble king, is that they are all imprisoned by circumstance in the ghastly grey horror that is the provincial, suburban uniformity of dreary middle England distinguished by fat-bellied, track-suited, tattooed oafs and equally repulsive cellulite ridden wives and will never achieve their ambition of quitting Engerlandia not least because they cannot qualify for residence elsewhere, not even in Thailand.

Poor bastards are all doomed to rot and end their days bouncing off the walls in some council funded death house because of their dementia.

The researchers believe it is the first study to demonstrate profound anhedonia - the clinical definition for a loss of ability to experience pleasure - in people with FTD.

Anhedonia is also common in people with depression, bipolar disorder and obsessive-compulsive disorder and can be particularly disabling for the individual.

Originally Posted by taxexile

s.a.


that just about sums it up perfectly.

there is fun to be had poking a stick at some of the angrier and more sensitive characters here, baiting them with observations and insults and knowing that in their umbrage they cannot resist replying in an idiotic, infantile, repetitive and self righteous manner, usually but not always including false accusations of miserableness, ethnicity, failure, homosexuality, being old, hypersexuality ( in the case of m.m.) and dementia.

surely the main purpose of a gutter forum like this is for the wiser, erudite and more perceptive amongst us to insult and banter with those here who for reasons i cannot begin to fathom choose to reveal intimate details of their lives. and their predictable responses merely confirm their utter and sheer idiocy.

long live the human zoo that is teak door, and in particular the pack of neanderthal apes (and baboons) who make a visit here so much fun.

.....