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The researchers looked at data collected on more than 1 million people from December 2020 through July 2021, a period that spanned both the alpha and delta variant waves in the U.K. Participants received two doses of either the Pfizer-BioNTech, Moderna or AstraZeneca vaccine.
Overall, less than 0.2 percent of the participants reported a breakthrough infection, with such cases more likely in people already considered to be vulnerable, including older adults or people with underlying illnesses.
When breakthrough infections did occur, most were mild — just 6 percent of people with breakthrough infections reported symptoms. What's more, vaccination was shown to cut the risk of hospitalization by more than two-thirds.