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Thread: Cancer sucks

  1. #751
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    Quote Originally Posted by nidhogg View Post
    Stage 4 anything does not end well I am afraid.
    There can be light at the end of the tunnel. I was diagnosed, out of the blue, with Stage 4 cancer less than 2 years ago - mainly in the colon and metastised to liver and possibly lungs. Spent almost a year doing chemo, with some Covid interruptions, which shrunk the tumours to what the surgeon deemed to be an operable size. Had an op less than a year ago to remove a section of the colon and a couple of spoonfuls of liver. Subsequent CT scans and colonoscopies show no signs of cancer. Nodules in lungs show no difference in size, indicating they may be benign.

    I know I am not out of the woods yet but hope my story gives hope to other sufferers. All treatment was at a Thai provincial hospital and, apart from some of the expensive targetted therapy chemicals, was covered by Thai Social Insurance. I opted for a private room for the few days post-op recovery after leaving ICU and this was only partially subsidised but the cost was similar to a decent hotel rate.

  2. #752
    I am not a cat
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    ^ Wishing you continued success in your fight.

  3. #753
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    Quote Originally Posted by nidhogg View Post
    ^ Wishing you continued success in your fight.

    Ditto...

  4. #754
    Guest Member S Landreth's Avatar
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    Fvck off jeff

    Cancer deaths down 33 percent in 30 years

    Cancer deaths in the U.S. have decreased by 33 percent over the past three decades, according to a new study from the American Cancer Society.

    The study — published on Thursday in CA: A Cancer Journal for Clinicians — estimated that this has resulted in about 3.8 million fewer deaths.

    After peaking in 1991, the mortality rate from cancer has continued to fall over the last 30 years due to a decrease in smoking and improved cancer detection and treatment, according to the study.

    This trend continued in 2020 — the most recent year for which data is available — with another 1.5 percent decrease in mortality rates compared to 2019.

    Two times more deaths were averted among men than among women —about 2.6 million compared to about 1.2 million — which the study attributed to a higher peak and faster decline in the death rate among men. Men still have a higher mortality rate from cancer than woman, despite this rapid decrease.

    A drop in mortality rates from lung cancer has been a particular driver of this trend, the study noted. However, lung cancer remains among the most deadly forms of cancer, holding the highest death rate for both men and women.

    Cancer was the second-leading cause of death in the U.S. in 2020, behind heart disease and followed by COVID-19.
    Keep your friends close and your enemies closer.

  5. #755
    Guest Member S Landreth's Avatar
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    Aussie Scientists Solve Mystery of Rare Cancer Causes

    2,460 Australians will be diagnosed with a sarcoma in 2023 One of the most common cancers in children First-ever genetic map identifies important new genes that cause sarcoma

    Research led by Omico, the Garvan Institute of Medical Research and UNSW Sydney has generated the first comprehensive genetic map of sarcomas, identifying several new important genes that when inherited can cause this deadly cancer. The research has wide implications for people living with sarcoma and their families – allowing detection of the cancer earlier and potentially improving survival for patients.

    Sarcomas are rare cancers arising in bone, muscle, fat, or cartilage. Often occurring in children and young adults, sarcomas make up about 20% of the cancers diagnosed in people under the age of 20.

    To date, there has been little research into the genetic basis of sarcomas. Now, a new global research study has generated a comprehensive map of how the inheritance of genes may impact families affected by sarcoma. Published this week in the prestigious journal, Science*, the Australian-led research revealed that one in 14 individuals diagnosed with sarcoma carry a clinically important gene that explains why the cancer arose. In addition, the research team identified a previously unrecognised genetic pathway specific to sarcomas, opening up new cancer biology required to improve health outcomes.

    Lead author of the paper, Dr Mandy Ballinger, Group Leader at the Garvan Institute of Medical Research and Conjoint Senior Lecturer at UNSW Medicine & Health, says “The findings uncovered by this research are so important, because by understanding how individuals develop sarcomas, we move closer to earlier detection and better treatments.”

    Jonathan Granek was diagnosed with a sarcoma at 26 years of age. Jonathan says “Receiving a sarcoma diagnosis can be devastating. This research offers hope to sarcoma patients, because it increases the chance of a diagnosis at an early and curable stage.”

    Professor David Thomas, CEO of Omico, Head of the Genomic Cancer Medicine Laboratory at the Garvan Institute of Medical Research and Conjoint Professor at UNSW Medicine & Health, led the research study. Professor Thomas says “Cancer is fundamentally a genetic disease, and genomics is the key to unlocking its secrets. This international collaboration has developed new methods for mapping the genetic basis for cancer and identified new heritable pathways that increase cancer risk. These findings fill important gaps in the missing heritability of cancer.”

    Associate Professor Kathy Tucker, Clinical Lead of the Hereditary Cancer Clinic at Prince of Wales Hospital, says “Why people develop these rare and devastating cancers has been a long-standing mystery. This paper fills in many missing pieces to the puzzle, which will change clinical practice.”

    With an increased understanding of risk, patients (and their families) can be empowered to better understand and manage underlying risks, detect any tumour occurrences much earlier, and make better, and more personalised decisions about treatments that can lead to far better outcomes.

    The research used data collected from the International Sarcoma Kindred Study (ISKS) and the Genetic Cancer Risk in the Young (RisC) studies. The ISKS, established in Australia in 2008, is the largest sarcoma genetic study in the world, including more than 3,500 families recruited from 23 cancer centres in seven countries. The research has been supported by Omico, NSW Office of Medical Research, National Health & Medical Research Council, Cancer Institute NSW, Cancer Australia, the Australian and New Zealand Sarcoma Alliance, the Liddy Shriver Sarcoma Initiative, and the Rainbows for Kate Foundation.

    Omico is a non-profit nationwide network of research and treatment centres that conducts research in precision medicine, with a particular focus on rare and less common cancers. Precision medicine is a tailored approach to disease risk management and treatment that takes into account differences in people’s genetic makeup, environments, and lifestyles. It is underpinned by genetic and genomic testing (sequencing), the results of which enable better prediction, prevention, diagnosis and treatment of disease.

    Global study identifies genes that cause sarcoma | UNSW Newsroom

  6. #756
    Guest Member S Landreth's Avatar
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    Banana Boat sunscreen recall expansion

    Banana Boat expands sunscreen recall due to cancer risk

    The company behind Banana Boat is recalling more of its sunscreen products due to the presence of a cancer-causing chemical.

    On Jan. 27, Edgewell Personal Care Company announced that it is expanding its nationwide recall of hair and scalp sunscreen sprays that was initially issued in July 2022. The recall was initiated because a review found unexpected levels of benzene came from the propellant even though it is not an ingredient in any Banana Boat product.

    The U.S. Food and Drug Administration (FDA) said benzene is classified as a human carcinogen that can potentially result in cancers including leukemia and blood cancer of the blood marrow. It can also cause life-threatening blood disorders.

    The Centers for Disease Control and Prevention says benzene works by causing cells to not function correctly. For example, it can cause bone marrow to not produce enough red blood cells. It can also damage the immune system by changing blood levels of antibodies and causing the loss of white blood cells.

    The CDC says people are exposed to benzene every day, including from tobacco smoke, gas stations, exhaust and industrial emissions. Indoors, people can get exposed to benzene from glues, paints, furniture wax and detergents.

    The company says daily exposure to benzene in the recalled products would not be expected to cause adverse health consequences, according to an independent health assessment using established exposure modeling guidelines.

    Anyone with the recalled product should stop using it and throw it out. They can get a refund by contacting Edgewell Personal Care at 1-888-686-3988 Monday through Friday, 9 a.m. to 6 p.m. They can also visit Banana Boat US for more information and to learn how to receive reimbursement for eligible products.

    Anyone who suffered adverse reactions or quality problems due to the use of the product should report it to the FDA’s MedWatch Adverse Event Reporting program in the following ways:



  7. #757
    Thailand Expat misskit's Avatar
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    After a great week long rally, Mr. MK had a massive cerebral hemorrhage and passed away. He was spared all of the pain and suffering he faced. I am so sad.

  8. #758
    Guest Member S Landreth's Avatar
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    I do hope never to mourn a spouse. Heart-breaking

    So sorry to hear you lost your husband.

  9. #759
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    Deepest condolences MK, but at least
    He was spared all of the pain and suffering

  10. #760
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    So sorry to hear that MK. My deepest condolences to you.

  11. #761
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    Quote Originally Posted by misskit View Post
    Mr. MK had a massive cerebral hemorrhage and passed away.
    Deepest sympathies MK. Truly sorry for your loss.

  12. #762
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    My deepest condolences, misskit. Hugs.

    RIP Mr. MK.

  13. #763
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    Sorry to hear that he lost the fight but you still have the fond memories MK.

    May your Hubby RIP.

  14. #764
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    My sincerest condolences Miss K. I cannot offer anything to console you on your loss other than I am sure you will in time come to think of the many happy memories that you have shared together. Hoping you have family and friends around you at this sad time. I and I'm sure everyone here on TD are thinking of you and your sad loss.
    RIP Mr K.

  15. #765
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    So sorry to read this MK. You must be devastated. My sincere condolences.

  16. #766
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    Quote Originally Posted by misskit View Post
    He was spared all of the pain and suffering he faced. I am so sad.
    So sorry to hear that MK, as you say at least it was quick which is a blessing.

  17. #767
    Thailand Expat misskit's Avatar
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    You fellow’s messages helped me though some dark days. Thank you.

  18. #768
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    We are always here if you need to chat or vent. I lost both my stepfather and uncle to cancer in the last five years.

  19. #769
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    very sorry to hear that MK
    my condolences

  20. #770
    Guest Member S Landreth's Avatar
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    ‘Bond villain’ DNA could transform cancer treatment, scientists say

    Scientists have pinpointed pieces of DNA which, they say, act like Bond villains in the way they help cancers spread. These microscopic agents have also been shown to be responsible for helping tumours gain resistance to anti-cancer drugs.

    The discovery of these bits of genetic material – known as extrachromosomal DNA or ecDNA – could revolutionise the treatments of some of the most aggressive tumours that affect people today, add the researchers.

    “The discovery of how these bits of DNA behave inside our bodies is a gamechanger,” said Professor Paul Mischel of California’s Stanford university, one of the leaders of the programme. “We believe they are responsible for a large number of the more advanced, most serious cancers affecting people today. If we can block their activities, we can block the spread of these cancers.”

    Made up of tiny loops of DNA, these genetic villains survive outside the chromosomes which are our cells’ main repositories of genetic material and which direct the growth of our bodies and determine our individual characteristics. The existence of these smaller units was revealed years ago but their importance in cancer has only now been uncovered.

    “We have found that ecDNA act as cancer-causing genes that have somehow separated themselves from a person’s chromosomes and have started to behave in ways that circumvent the normal rules of genetics,” said Stanford university geneticist Howard Chang. “They behave like villains in a Bond film. At first, in a film, you see different explosions, killings and disasters occurring and you don’t know why they are happening or who is responsible. Then, at some point, you finally meet the villain who is revealed to be the agent of all this mayhem.”

    Hence the parallel with ecDNA. Scientists could see all sorts of strange, unaccountable things happening – tumours spreading with unanticipated speed or cancers becoming resistant to drugs that had initially been effective in attacking them. “Now, at last, we have revealed the agents of these events. It is ecDNA,” added Chang.

    The breakthrough is part of a major initiative, known as the Cancer Grand Challenges, that is backed by Cancer Research UK and the US National Cancer Institute. It has been set up to fund multidisciplinary research programmes that could develop novel routes for tackling cancer. In this case, it has provided Ł20m to fund the work on ecDNA’s involvement in cancers and has involved teams of chemists, biologists, geneticists, mathematicians, and immunologists – based in California, London and other centres – collaborating to show how these little loops of DNA cause such biological harm.

    In recent years, scientists have shown that tumours occur because normal genes in a cell go wrong and cause that cell to divide uncontrollably. The end result is a tumour. These genes are known as oncogenes and they can be targeted by a range of drugs and therapies.

    “However, resistance to those drugs or therapies often appears after a while, and this allows the cancer to return. We have now discovered that, in some of the most aggressive forms of cancer, the oncogenes aren’t where we thought they were. They are actually on extrachromosomal DNA,” said Mischel.“The vulnerable gene had quickly disappeared when threatened by cancer drugs and was hidden in ecDNA. Then it reappeared once it was safe for it to start causing damage again.”

    From this perspective, ecDNA is not just a villain. It is a criminal mastermind. “It can almost completely disappear from a tumour and then come back after you stop drug treatments,” said Professor Charlie Swanton of the Francis Crick Institute in London. “That provides almost infinite adaptability.”

    Nevertheless scientists are confident that they will be able to find ways of removing ecDNA from patients. “It should be noted that ecDNA is a feature of cancer and not healthy tissue, so that raises hopes that when we find ways to remove it – through drugs or some form of therapy – then it will not have unpleasant side-effects,” said Dr Mariam Jamal-Hanjani of University College London Cancer Institute.

    “The crucial point is that once we have found the cause of the problem then it becomes possible to develop and try out all sorts of drugs and therapies to tackle that.”

    This point was backed by Chang: “We are now looking to pinpoint the achilles heel of ecDNA and have identified a protein that helps hold it together. We have also discovered a drug that has a promising effect on this protein. And in the coming years, we will test a lot more until we find the best one to tackle ecDNA and halt its pro-cancerous activities. It will take time but I am confident we will get there.”

  21. #771
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    Very sad news, sincere condolences.

  22. #772
    Guest Member S Landreth's Avatar
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    Scientists have identified a surprising new source of “forever chemicals” awash in global wastewater: the ubiquitous paper product dangling next to most of the planet’s toilets.

    Toilet paper is the latest product that could be contaminating environments worldwide with cancer-linked per- and polyfluoroalkyl substances (PFAS), according to a study, published Wednesday in Environmental Science & Technology Letters.

    Notorious for their presence in jet fuel firefighting foam and industrial discharge, these so-called forever chemicals are linked to a variety of illnesses, such as testicular and kidney cancers.

    There are thousands of types of PFAS, many of which are also key ingredients in household items and cosmetics — and some of which end up flowing down the drain.

    The study authors, who had recently investigated the presence of a major type of PFAS in biosolids, decided to continue their quest with toilet paper.

    “We asked ourselves where is the chemical used, and one product is paper,” corresponding author Timothy Townsend, a professor of environmental engineering at the University of Florida, told The Hill in an email.

    “Hence the look at toilet paper,” he said.

    Paper production processes often include PFAS as additives during the wood-to-pulp conversion process, the authors explained.

    These compounds are used as a wetting agent to boost the efficiency of the pulping process — making paper mills a known source of environmental contamination, according to the study.

    Not only might standard toilet paper contain PFAS, but so too could rolls made from recycled paper — as they may be made with contaminated fibers, the authors found.

    The researchers asked a volunteer network of students and professors to collect toilet paper sold in North, South and Central America, as well as in Africa and Western Europe. In addition, they evaluated sewage sludge samples from eight wastewater treatment plants in Florida.

    They then extracted PFAS from both the paper particles and sludge solids and analyzed them for 34 different compounds, according to the study.

    The main substances they detected were “diPAPs” — precursor compounds that can convert into other kinds of PFAS such as the potentially carcinogenic PFOA.

    After combining their results with sewage data from other studies and accounting for per capita toilet paper usage, the scientists observed that toilet paper was responsible for about 4 percent of the most common type of diPAP in U.S. and Canadian sewage.

    But in Sweden and France, they saw this figure climb to 35 percent and 89 percent, respectively.

    “Despite the fact that North Americans use more toilet paper than people living in many other countries, the calculated percentages suggest that most PFAS enter the U.S. wastewater systems from cosmetics, textiles, food packaging or other sources,” the authors stated.

    The study, they concluded, identified toilet paper as a source of PFAS pollution in wastewater treatment systems — and a major source of contamination in certain places around the globe.

    While the scientists evaluated both nonrecycled and recycled toilet paper, Townsend said they did not assess other alternatives, such as bamboo-based rolls. They determined, however, that diPAP concentration did not differ based on recycled content.

    The authors expressed some optimism that consumer product choices and discard practices could ultimately help inform regulations aimed at curbing PFAS content in wastewater.

    “This reduction in PFAS is critical, since wastewater effluent and sludge are commonly reused for irrigation and/or land application,” the scientists stated.

    “Research has already shown that these two pathways pose a risk for human and environmental exposure to PFAS,” they added.

    While Townsend said that his team’s goal was to better understand PFAS sources, he expressed hope that such research could help influence future policy.

    “Decision makers will be better equipped to implement changes if we better understand the sources and fate of PFAS entering our wastewater treatment plants and landfills,” he said.

  23. #773
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    ^ All hail the bum gun.

  24. #774
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    Visited my hometown/ my mom this weekend. Saw an old friend, whom I haven't seen in many years. We chatted about our present lives, our common friends, etc - we once belonged to the same organization but are of different ages. I found out that our common friend, female, died of cancer. To my knowledge, she didn't smoke, drink or do drugs. According to the friend who told me the story, it was all very sudden - maybe she was stage 4 already when diagnosed. She was only 48 years old.

    RIP Marilen. Cancer sucks...

  25. #775
    Guest Member S Landreth's Avatar
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    In reference to Kate’s last post. Young adults leaving us

    Quote Originally Posted by katie23 View Post
    I found out that our common friend, female, died of cancer. She was only 48 years old.
    Last week I was listening to a 47-year-old woman on the radio talking about her colonoscopy experience. She told a story about how her doctor recommended she take a test to detect colon cancer. She was younger than 40 and thought to herself.....That’s for older people. Not me.

    She was finally convinced and took the test when she was 45 and they found early-stage cancer.

    __________

    From the link above.........

    Colon cancer diagnoses at younger ages

    Adults across the nation are being diagnosed with colon and rectal cancers at younger ages. Now, 1 in 5 new cases are among people in their early 50s or younger, according to a new report by the American Cancer Society. There have also been more diagnoses of advanced stages of cancer.

    Colorectal cancer is the second most common cause of cancer death in the United States, and it is the leading cause of cancer-related deaths in men younger than 50. There is also a rising impact on young Hispanic adults. The American Cancer Society and the US Preventative Task Force recommend adults with an average risk now get their first colonoscopy at 45.

    ___________

    Couple notes.

    Girlfriend who is younger than I am has been getting a colonoscopy every two years for the past 6 years. Last test was just a couple weeks ago. 6 polyps removed and why the doctor requests the two year period.

    My next appointment will be in two weeks.

    Take a test. Might save you and your family a world of pain.
    Last edited by S Landreth; 27-03-2023 at 05:33 AM.

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