Several people are feared dead and as many as 35 injured in a collision involving 27 vehicles on the M5 motorway in Somerset.
An Avon and Somerset Police spokesman confirmed that "some" people have "tragically lost their lives".
There are reports that 10 others have sustained "life changing" injuries.
Some 20 light vehicles and six articulated lorries were involved in the smash on the motorway close to junction 25 near Taunton at around 8.30pm.
At least four people who were trapped have been cut free by firefighters.
Video footage from the scene shows several vehicles engulfed in flames and debris strewn across the road. A number of burning lorries are on their side.
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