The 171st Manchester derby
Manchester City will be without captain Vincent Kompany, who suffered a recurrence of a calf injury against Dynamo Kiev in midweek.
Fellow defender Nicolas Otamendi, who picked up a dead leg in that game, will be assessed ahead of Saturday's match.
United's Ander Herrera is a doubt with a groin problem that forced him to miss the Europa League clash with Liverpool.
Ashley Young and Cameron Borthwick-Jackson have both returned to training after injury and could feature.
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Both City and United will be without their captains for the Manchester derby.
Man City
1Hart
3Sagna
26Demichelis
20Mangala
22Clichy
42Y Touré
25Fernandinho
15Jesús Navas
21Silva
7Sterling
10Agüero
Substitutes
5Zabaleta
6Fernando
11Kolarov
13Caballero
14Bony
72Iheanacho
76Garcia Alonso
Man Utd
1de Gea
36Darmian
12Smalling
17Blind
5Rojo
16Carrick
28Schneiderlin
35Lingard
8Mata
9Martial
39Rashford
Substitutes
7Depay
11Januzaj
20Romero
25A Valencia
27Fellaini
31Schweinsteiger
51Fosu-Mensah
C'mon City:bananaman: